A folic acid-enriched diet attenuates prostate involution in response to androgen deprivation.

ABSTRACT:

Background

Serum folate concentrations in the United States have risen since dietary folic acid fortification was first mandated in 1998. Although maternal folic acid offers protection against neural tube defects in conceptuses, its impact on other organ systems and life stages have not been fully examined. Here, we used a mouse model to investigate the impact of a Folic acid (FA) enriched diet on prostate homeostasis and response to androgen deprivation.

Methods

Male mice were fed a control diet (4 mg FA/kg feed) or a folic acid supplemented diet (24 mg FA/kg feed) beginning at conception and continuing through early adulthood, when mice were castrated.

Results

We made the surprising observation that dietary FA supplementation confers partial resistance to castration

SUBMITTER: Joseph DB 

PROVIDER: S-EPMC6420320 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature