Inflammation and dimensions of reward processing following exposure to the influenza vaccine.

ABSTRACT:

Background

Alterations in reward processing are a central feature of depression and may be influenced by inflammation. Indeed, inflammation is associated with deficits in reward-related processes in animal models and with dysregulation in reward-related neural circuitry in humans. However, the downstream behavioral manifestations of such impairments are rarely examined in humans.

Methods

The influenza vaccination was used to elicit a mild inflammatory response in 41 healthy young adults (age range: 18-22, 30 female). Participants provided blood samples and completed behavioral measures of three key aspects of reward-reward motivation, reward learning, and reward sensitivity-before and 1 day after receiving the influenza vaccine.

Results

The influenza vaccine led to mi

SUBMITTER: Boyle CC 

PROVIDER: S-EPMC6420390 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature