Brain cholesterol metabolism and Parkinson's disease.

ABSTRACT:

Background

Circulating cholesterol levels have been linked to PD, but not directly to brain physiology.

Objective

To assess whether brain cholesterol metabolism is related to PD.

Methods

Sixty PD patients and 64 controls were recruited from an academic movement disorder clinic (2009-2012). Thirty-five PD patients and 33 controls returned approximately 36 months later. Fasting plasma (S)24-OH-cholesterol (brain-derived cholesterol metabolite) and 27-OH-cholesterol (peripheral cholesterol metabolite) were quantified. Odds ratios for PD were derived from logistic regression models, adjusting for potential confounders. Relationships between the oxysterols and clinical measurements were explored using Spearman correlation coefficients.

Results

Mean age of PD subject

SUBMITTER: Huang X 

PROVIDER: S-EPMC6420391 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature