Hyperperfusion of Frontal White and Subcortical Gray Matter in Autism Spectrum Disorder.

ABSTRACT: BACKGROUND:Our aim was to assess resting cerebral blood flow (rCBF) in children and adults with autism spectrum disorder (ASD). METHODS:We acquired pulsed arterial spin labeling magnetic resonance imaging data in 44 generally high-functioning participants with ASD simplex and 66 typically developing control subjects with comparable mean full-scale IQs. We compared rCBF values voxelwise across diagnostic groups and assessed correlations with symptom scores. We also assessed the moderating influences of participant age, sex, and IQ on our findings and the correlations of rCBF with N-acetylaspartate metabolite levels. RESULTS:We detected significantly higher rCBF values throughout frontal white matter and subcortical gray matter in participants with ASD. rCBF correlated positively with social

SUBMITTER: Peterson BS 

PROVIDER: S-EPMC6420395 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature