Estrogen deficiency impairs integrin α_vβ₃-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling.

ABSTRACT: The integrin α_vβ₃ has been shown to play an important role in osteocyte mechanotransduction. It has been reported that there are fewer β₃ integrin-containing cells in osteoporotic bone cells. Osteocytes cultured in vitro under estrogen deficient conditions demonstrate altered mechanotransduction. However, it is unknown whether the altered mechanotransduction in estrogen deficient osteocytes is directly associated with defective α_vβ₃ expression or signalling. The objective of this study is to investigate the role of estrogen deficiency for regulating MLO-Y4 cell morphology, α_vβ₃ expression, focal adhesion formation and mechanotransduction by osteocytes. Here, we report that estrogen withdrawal leads to a smaller fo

SUBMITTER: Geoghegan IP 

PROVIDER: S-EPMC6420496 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature