Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations.

ABSTRACT:

Purpose

The purpose of the study was to compare the morphokinetic parameters of embryos carrying balanced chromosomal translocations with those carrying unbalanced chromosomal translocations using time-lapse microscopy.

Methods

The study group included 270 embryos that underwent biopsies on day 3 for preimplantation genetic diagnosis (PGD) for chromosomal translocations in our unit between 2013 and 2015. All embryos were incubated under time-lapse microscopy and evaluated for timing of developmental events up to day 5. The timing of these events was compared between balanced and unbalanced embryos, potentially viable and nonviable variants, and maternal versus paternal inheritance of the translocation.

Results

The PGD analysis found that 209 (77%) of the 270 biopsied

SUBMITTER: Amir H 

PROVIDER: S-EPMC6420524 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature