Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.

ABSTRACT: There is currently an epidemic of opioid use, overdose, and dependence in the United States. Although opioid dependence (OD) is more prevalent in men, opioid relapse and fatal opioid overdoses have recently increased at a higher rate among women. Epigenetic mechanisms have been implicated in the etiology of OD, though most studies to date have used candidate gene approaches. We conducted the first epigenome-wide association study (EWAS) of OD in a sample of 220 European-American (EA) women (140 OD cases, 80 opioid-exposed controls). DNA was derived from whole blood samples and EWAS was implemented using the Illumina Infinium HumanMethylationEPIC array. To identify differentially methylated CpG sites, we performed an association analysis adjusting for age, estimates of cell proportions, smo

SUBMITTER: Montalvo-Ortiz JL 

PROVIDER: S-EPMC6420601 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature