The Reciprocity between Radiotherapy and Cancer Immunotherapy.

ABSTRACT: The clinical success of immune checkpoint inhibitors in treating metastatic and refractory cancers has generated significant interest in investigating their role in treating locally advanced diseases, thus requiring them to be combined with standard treatments in the hope of producing synergistic antitumor responses. Radiotherapy, in particular, has long been hypothesized to have actions complementary to those of immune checkpoint blockade, and a growing body of evidence indicates that cancer immunotherapy may also have radiosensitizing effects, which would provide unique benefit for locoregional treatments. Recent studies have demonstrated that when immune cells are activated by immunotherapeutics, they can reprogram the tumor microenvironment in ways that may potentially increase the rad

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6420874 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature