Metabolic heterogeneity underlies reciprocal fates of T_H17 cell stemness and plasticity.

ABSTRACT: A defining feature of adaptive immunity is the development of long-lived memory T cells to curtail infection. Recent studies have identified a unique stem-like T-cell subset amongst exhausted CD8-positive T cells in chronic infection^1-3, but it remains unclear whether CD4-positive T-cell subsets with similar features exist in chronic inflammatory conditions. Amongst helper T cells, T_H17 cells have prominent roles in autoimmunity and tissue inflammation and are characterized by inherent plasticity^4-7, although how such plasticity is regulated is poorly understood. Here we demonstrate that T_H17 cells in a mouse model of autoimmune disease are functionally and metabolically heterogeneous; they contain a subset with stemness-associated features but l

SUBMITTER: Karmaus PWF 

PROVIDER: S-EPMC6420879 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature