Simultaneous Bayesian inference of phylogeny and molecular coevolution.

ABSTRACT: Patterns of molecular coevolution can reveal structural and functional constraints within or among organic molecules. These patterns are better understood when considering the underlying evolutionary process, which enables us to disentangle the signal of the dependent evolution of sites (coevolution) from the effects of shared ancestry of genes. Conversely, disregarding the dependent evolution of sites when studying the history of genes negatively impacts the accuracy of the inferred phylogenetic trees. Although molecular coevolution and phylogenetic history are interdependent, analyses of the two processes are conducted separately, a choice dictated by computational convenience, but at the expense of accuracy. We present a Bayesian method and associated software to infer how many and whic

SUBMITTER: Meyer X 

PROVIDER: S-EPMC6421416 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature