Transcriptome-Wide Association Study Identifies Susceptibility Loci and Genes for Age at Natural Menopause.

ABSTRACT:

Objective

To identify novel susceptibility genes for age at natural menopause (ANM).

Methods

Using transcription data generated in tissues from normal hypothalami (n = 73) and ovaries (n = 68) and high-density genotyping data provided by the Genotype-Tissue Expression (GTEx) database, we built 16 164 genetic models to predict gene expression across the transcriptome in these tissues. We used these models and summary statistics data from genome-wide association studies (GWAS) of ANM generated in 69 360 women of European ancestry to identify genes with their predicted expression related to ANM.

Results

We found the predicted expression of 34 genes to be significantly associated with ANM at a Bonferroni-corrected threshold of P < 3.09 ×10^-6. These include 4 ge

SUBMITTER: Shi J 

PROVIDER: S-EPMC6421625 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature