NAT2 variants and toxicity related to anti-tuberculosis agents: a systematic review and meta-analysis.

ABSTRACT:

Background

Tuberculosis (TB) patients receiving anti-tuberculosis treatment may experience serious adverse drug reactions (ADRs) such as hepatotoxicity. Variants of the N-acetyltransferase 2 (NAT2) gene may increase the risk of experiencing such toxicity events.

Objective

To provide a comprehensive evaluation of the evidence base for associations between NAT2 variants and anti-tuberculosis drug-related toxicity.

Method

This was a systematic review and meta-analysis. We searched for studies in Medline, PubMed, EMBASE, BIOSIS and Web of Science. We included data from 41 articles (39 distinct cohorts of patients). We pooled effect estimates for each genotype on each outcome using meta-analyses stratified by country.

Results

We assessed the qua

SUBMITTER: Richardson M 

PROVIDER: S-EPMC6421944 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature