Ontology highlight
ABSTRACT:
SUBMITTER: Bard JAM
PROVIDER: S-EPMC6422034 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Annual review of biochemistry 20180413
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The proteasome's cellular functions range from general protein homeostasis and stress response to the control of vital processes such as cell division and signal transduction. To reliably process all the proteins presented to it in the complex cellular environment, the proteasome must combine high promiscuity with exceptio ...[more]