Craniospinal irradiation as part of re-irradiation for children with recurrent intracranial ependymoma.

ABSTRACT:

Background

The goal of this study was to evaluate outcomes in children with relapsed, molecularly characterized intracranial ependymoma treated with or without craniospinal irradiation (CSI) as part of a course of repeat radiation therapy (re-RT).

Methods

This was a retrospective cohort study of 31 children. Patients with distant relapse received CSI as part of re-RT. For patients with locally recurrent ependymoma, those treated before 2012 were re-irradiated with focal re-RT. In 2012, institutional practice changed to offer CSI, followed by boost re-RT to the site of resected or gross disease.

Results

Median follow-up was 5.5 years. Of 9 patients with distant relapse after initial RT, 2-year freedom from progression (FFP) and overall survival (OS) were 12.5% and 62.5

SUBMITTER: Tsang DS 

PROVIDER: S-EPMC6422429 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature