Task activations produce spurious but systematic inflation of task functional connectivity estimates.

ABSTRACT: Most neuroscientific studies have focused on task-evoked activations (activity amplitudes at specific brain locations), providing limited insight into the functional relationships between separate brain locations. Task-state functional connectivity (FC) - statistical association between brain activity time series during task performance - moves beyond task-evoked activations by quantifying functional interactions during tasks. However, many task-state FC studies do not remove the first-order effect of task-evoked activations prior to estimating task-state FC. It has been argued that this results in the ambiguous inference "likely active or interacting during the task", rather than the intended inference "likely interacting during the task". Utilizing a neural mass computational model, we v

SUBMITTER: Cole MW 

PROVIDER: S-EPMC6422749 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature