Preventing secondary exposure to women from men applying a novel nestorone/testosterone contraceptive gel.

ABSTRACT:

Background

Testosterone (T)/Nestorone (NES) combination gel is a potential transdermal male contraceptive that suppresses gonadotropins and spermatogenesis. Transfer of transdermal T from men to women can be prevented by washing or covering application sites with clothing.

Objectives

We hypothesized that showering or wearing a shirt over gel application sites would prevent secondary exposure of T and NES to a woman after close skin contact.

Materials and methods

Twelve healthy male and 12 healthy female participants were recruited. Men applied T/NES 62 mg/8 mg gel to their shoulders and upper arms. Two hours after application, female partners rubbed the application site for 15 min. Exposure in the female partner was assessed under three conditions: a shirt covered the

SUBMITTER: Yuen F 

PROVIDER: S-EPMC6422752 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature