Secukinumab: A Review in Ankylosing Spondylitis.

ABSTRACT: Secukinumab (Cosentyx^®), a first-in-class fully human monoclonal antibody against interleukin-17A, is approved in several countries, including the USA and those of the EU, for the treatment of ankylosing spondylitis (AS). Subcutaneous secukinumab significantly improved the clinical signs and symptoms of AS versus placebo in three of four phase III trials. The benefits of secukinumab were generally seen regardless of whether patients had or had not received previous tumour necrosis factor (TNF) inhibitor therapy, and were sustained during longer-term (up to 5 years) treatment. Secukinumab was also associated with improvements in spinal mobility, physical function, health-related quality of life and work productivity in some of the trials. In MEASURE 1, secukinumab reduced inflamm

SUBMITTER: Blair HA 

PROVIDER: S-EPMC6422944 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature