Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence.

ABSTRACT:

Purpose

Most triple-negative breast cancer (TNBC) patients exhibit an incomplete response to neoadjuvant chemotherapy, resulting in chemo-residual tumor cells that drive tumor recurrence and patient mortality. Accordingly, strategies for eliminating chemo-residual tumor cells are urgently needed. Although stromal cells contribute to tumor cell invasion, to date, their ability to influence chemo-residual tumor cell behavior has not been examined. Our study is the first to investigate cross-talk between adipose-derived stem cells (ASCs) and chemo-residual TNBC cells. We examine if ASCs promote chemo-residual tumor cell proliferation, having implications for tumor recurrence.

Methods

ASC migration toward chemo-residual TNBC cells was tested in a transwell migration assay. Impor

SUBMITTER: Lyes MA 

PROVIDER: S-EPMC6422973 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature