Simulations of Protein Adsorption on Nanostructured Surfaces.

ABSTRACT: Recent technological advances have allowed the development of a new generation of nanostructured materials, such as those displaying both mechano-bactericidal activity and substrata that favor the growth of mammalian cells. Nanomaterials that come into contact with biological media such as blood first interact with proteins, hence understanding the process of adsorption of proteins onto these surfaces is highly important. The Random Sequential Adsorption (RSA) model for protein adsorption on flat surfaces was modified to account for nanostructured surfaces. Phenomena related to the nanofeature geometry have been revealed during the modelling process; e.g., convex geometries can lead to lower steric hindrance between particles, and hence higher degrees of surface coverage per unit area. The

SUBMITTER: Manzi BM 

PROVIDER: S-EPMC6423022 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature