Pilot study of DNA methylation, molecular aging markers and measures of health and well-being in aging.

ABSTRACT: Relations of DNA methylation markers to other biological aging markers and to psychosocial, behavioral, and health measures remain unclear. The sample included 23 participants (n?=?11 cases with psychiatric diagnoses and n?=?12 controls without current or lifetime psychiatric disorder), balanced by age and sex. Genomic DNA was extracted from blood samples; the following were performed: genome-wide DNA methylation assay using Illumina 850k methylationEPIC; PCR assays for relative telomere length (RTL) and mitochondrial DNA copy number (mtCN). Exposures were: case status; depression and anxiety symptoms; psychosocial support; subjective and objective cognition. Outcomes were: DNA methylation age (DNAm age); RTL; mtCN; extrinsic and intrinsic epigenetic age acceleration (EEAA and IEAA). Stronger correlation with chronological age was observed for DNAm age (??=?0.86; p?

SUBMITTER: Vyas CM 

PROVIDER: S-EPMC6423054 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature