Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae.

ABSTRACT: HIV-1 sexual transmission occurs mainly via mucosal semen exposures. In the female reproductive tract (FRT), seminal plasma (SP) induces physiological modifications, including inflammation. An effective HIV-1 vaccine should elicit mucosal immunity, however, modifications of vaccine responses by the local environment remain to be characterized. Using a modified vaccinia virus Ankara (MVA) as a vaccine model, we characterized the impact of HIV-1⁺ SP intravaginal exposure on the local immune responses of non-human primates. Multiple HIV-1⁺ SP exposures did not impact the anti-MVA antibody responses. However, SP exposures revealed an anti-MVA responses mediated by CD4⁺ T cells, which was not observed in the control group. Furthermore, the frequency and the qual

SUBMITTER: Marlin R 

PROVIDER: S-EPMC6423065 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature