[Ru(bpy)₂(NO)SO₃](PF₆), a Nitric Oxide Donating Ruthenium Complex, Reduces Gout Arthritis in Mice.

ABSTRACT: Monosodium urate crystals (MSU) deposition induces articular inflammation known as gout. This disease is characterized by intense articular inflammation and pain by mechanisms involving the activation of the transcription factor NFκB and inflammasome resulting in the production of cytokines and oxidative stress. Despite evidence that MSU induces iNOS expression, there is no evidence on the effect of nitric oxide (NO) donors in gout. Thus, the present study evaluated the effect of the ruthenium complex donor of NO {[Ru(bpy)₂(NO)SO₃](PF₆)} (complex I) in gout arthritis. Complex I inhibited in a dose-dependent manner MSU-induced hypersensitivity to mechanical stimulation, edema and leukocyte recruitment. These effects were corroborated by a decrease of histolo

SUBMITTER: Rossaneis AC 

PROVIDER: S-EPMC6423075 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature