CX₃CR1-CX₃CL1-dependent cell-to-cell Japanese encephalitis virus transmission by human microglial cells.

ABSTRACT: The neurotropic Japanese encephalitis virus (JEV) is responsible for Japanese encephalitis, an uncontrolled inflammatory disease of the central nervous system. Microglia cells are the unique innate immune cell type populating the brain that cross-communicate with neurons via the CX₃CR1-CX₃CL1 axis. However, microglia may serve as a viral reservoir for JEV. Human microglia are able to transmit JEV infectivity to neighbouring cells in a cell-to-cell contact-dependent manner. Using JEV-treated human blood monocyte-derived microglia, the present study investigates molecular mechanisms behind cell-to-cell virus transmission by human microglia. For that purpose, JEV-associated microglia were co-cultured with JEV susceptible baby hamster kidney cells under various conditions

SUBMITTER: Lannes N 

PROVIDER: S-EPMC6423114 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature