Reconstructing foot-and-mouth disease outbreaks: a methods comparison of transmission network models.

ABSTRACT: A number of transmission network models are available that combine genomic and epidemiological data to reconstruct networks of who infected whom during infectious disease outbreaks. For such models to reliably inform decision-making they must be transparently validated, robust, and capable of producing accurate predictions within the short data collection and inference timeframes typical of outbreak responses. A lack of transparent multi-model comparisons reduces confidence in the accuracy of transmission network model outputs, negatively impacting on their more widespread use as decision-support tools. We undertook a formal comparison of the performance of nine published transmission network models based on a set of foot-and-mouth disease outbreaks simulated in a previously free country,

SUBMITTER: Firestone SM 

PROVIDER: S-EPMC6423326 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature