Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample.

ABSTRACT: Interpretation of genetic association results is difficult because signals often lack biological context. To generate hypotheses of the functional genetic etiology of complex cardiometabolic traits, we estimated the genetically determined component of gene expression from common variants using PrediXcan (1) and determined genes with differential predicted expression by trait. PrediXcan imputes tissue-specific expression levels from genetic variation using variant-level effect on gene expression in transcriptome data. To explore the value of imputed genetically regulated gene expression (GReX) models across different ancestral populations, we evaluated imputed expression levels for predictive accuracy genome-wide in RNA sequence data in samples drawn from European-ancestry and African-ances

SUBMITTER: Petty LE 

PROVIDER: S-EPMC6423424 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature