GMASS: a novel measure for genome assembly structural similarity.

ABSTRACT:

Background

Thanks to the recent advancements in next-generation sequencing (NGS) technologies, large amount of genomic data, which are short DNA sequences known as reads, has been accumulating. Diverse assemblers have been developed to generate high quality de novo assemblies using the NGS reads, but their output is very different because of algorithmic differences. However, there are not properly structured measures to show the similarity or difference in assemblies.

Results

We developed a new measure, called the GMASS score, for comparing two genome assemblies in terms of their structure. The GMASS score was developed based on the distribution pattern of the number and coverage of similar regions between a pair of assemblies. The new measure was able to show structural sim

SUBMITTER: Kwon D 

PROVIDER: S-EPMC6423833 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature