The association between autoimmune disease and 30-day mortality among sepsis ICU patients: a cohort study.

ABSTRACT:

Introduction

Sepsis results from a dysregulated host response to an infection that is associated with an imbalance between pro- and anti-inflammatory cytokines. This imbalance is hypothesized to be a driver of patient mortality. Certain autoimmune diseases modulate the expression of cytokines involved in the pathophysiology of sepsis. However, the outcomes of patients with autoimmune disease who develop sepsis have not been studied in detail. The objective of this study is to determine whether patients with autoimmune diseases have different sepsis outcomes than patients without these comorbidities.

Methods

Using the Multiparameter Intelligent Monitoring in Intensive Care III database (v. 1.4) which contains retrospective clinical data for over 50,000 adult ICU stays, we com

SUBMITTER: Sheth M 

PROVIDER: S-EPMC6423870 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature