Evidence for liver energy metabolism programming in offspring subjected to intrauterine undernutrition during midgestation.

ABSTRACT:

Background

Maternal undernutrition programs fetal energy homeostasis and increases the risk of metabolic disorders later in life. This study aimed to identify the signs of hepatic metabolic programming in utero and during the juvenile phase after intrauterine undernutrition during midgestation.

Methods

Fifty-three pregnant goats were assigned to the control (100% of the maintenance requirement) or restricted (60% of the maintenance requirement from day 45 to day 100 of midgestation and realimentation thereafter) group to compare hepatic energy metabolism in the fetuses (day 100 of gestation) and kids (postnatal day 90).

Results

Undernutrition increased the glucagon concentration and hepatic hexokinase activity, decreased the body weight, liver weight and hepatic expre

SUBMITTER: Zhou X 

PROVIDER: S-EPMC6423887 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature