Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose.

ABSTRACT: Cocaine addiction is associated with compulsive drug-seeking, and exposure to the drug or to drug-associated cues leads to relapse, even after long periods of abstention. A variety of pharmacological targets and behavioral interventions have been explored to counteract cocaine addiction, but to date no market-approved medications for treating cocaine addiction or relapse exist, and effective interventions for acute emergencies resulting from cocaine overdose are lacking. We recently demonstrated that skin epidermal stem cells can be readily edited by using CRISPR (clustered regularly interspaced short palindromic repeats) and then transplanted back into the donor mice. Here, we show that the transplantation, into mice, of skin cells modified to express an enhanced form of butyrylcholineste

SUBMITTER: Li Y 

PROVIDER: S-EPMC6423967 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature