Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.

ABSTRACT: Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peritransplant management of the islet transplant recipient has resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or subtotal pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate postsurgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality of life is substantially improved. For patients with type 1 diabetes or insulin-deficient form

SUBMITTER: Rickels MR 

PROVIDER: S-EPMC6424003 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature