A nanoliter resolution implantable micropump for murine inner ear drug delivery.

ABSTRACT: Advances in protective and restorative biotherapies have created new opportunities to use site-directed, programmable drug delivery systems to treat auditory and vestibular disorders. Successful therapy development that leverages the transgenic, knock-in, and knock-out variants of mouse models of human disease requires advanced microsystems specifically designed to function with nanoliter precision and with system volumes suitable for implantation. Here we present results for a novel biocompatible, implantable, scalable, and wirelessly controlled peristaltic micropump. The micropump configuration included commercially available catheter microtubing (250 μm OD, 125 μm ID) that provided a biocompatible leak-free flow path while avoiding complicated microfluidic interconnects. Peristaltic pum

SUBMITTER: Forouzandeh F 

PROVIDER: S-EPMC6424108 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature