Evaluation of ¹¹C-Methionine PET and Anatomic MRI Associations in Diffuse Intrinsic Pontine Glioma.

ABSTRACT: The role of metabolic imaging in the diagnosis, treatment, and response assessment of diffuse intrinsic pontine glioma (DIPG) is poorly defined. We investigated the uptake of ¹¹C-methionine in pediatric patients with newly diagnosed DIPG and evaluated the associations of ¹¹C-methionine PET metrics with conventional MRI indices and survival outcomes. Methods: Twenty-two patients with newly diagnosed DIPG were prospectively enrolled on an institutional review board-approved investigational study of ¹¹C-methionine PET. All patients underwent baseline ¹¹C-methionine PET/CT, and initial treatment-response scans after chemotherapy or radiation therapy were obtained for 17 patients. Typical and atypical DIPGs were assessed clinically and radiogra

SUBMITTER: Tinkle CL 

PROVIDER: S-EPMC6424234 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature