Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina.

ABSTRACT: High-acuity vision in primates, including humans, is mediated by a small central retinal region called the fovea. As more accessible organisms lack a fovea, its specialized function and its dysfunction in ocular diseases remain poorly understood. We used 165,000 single-cell RNA-seq profiles to generate comprehensive cellular taxonomies of macaque fovea and peripheral retina. More than 80% of >60 cell types match between the two regions but exhibit substantial differences in proportions and gene expression, some of which we relate to functional differences. Comparison of macaque retinal types with those of mice reveals that interneuron types are tightly conserved. In contrast, projection neuron types and programs diverge, despite exhibiting conserved transcription factor codes. Key macaque

SUBMITTER: Peng YR 

PROVIDER: S-EPMC6424338 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature