Antibiotic prophylaxis and clinical outcomes among older adults with recurrent urinary tract infection: cohort study.

ABSTRACT:

Background

clinical guidelines recommend antibiotic prophylaxis for preventing recurrent urinary tract infections (UTIs), but there is little evidence for their effectiveness in older adults.

Methods

this was a retrospective cohort study of health records from 19,696 adults aged ≥65 with recurrent UTIs. We used prescription records to ascertain ≥3 months' prophylaxis with trimethoprim, cefalexin or nitrofurantoin. We used random effects Cox recurrent event models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risks of clinical recurrence (primary outcome), acute antibiotic prescribing and hospitalisation.

Results

of 4,043 men and 15,653 women aged ≥65 with recurrent UTIs, 508 men (12.6%) and 2,229 women (14.2%) were prescribed antibiotic prophyla

SUBMITTER: Ahmed H 

PROVIDER: S-EPMC6424374 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature