Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls.

ABSTRACT:

Introduction

Increasing evidence indicates that the development of type 2 diabetes is driven by chronic low grade beta-cell inflammation. However, it is unclear whether pancreatic inflammation can be noninvasively visualized in type 2 diabetes patients. We aimed to assess pancreatic 18F-FDG uptake in type 2 diabetes patients and controls using 18F-fluorodeoxylglucose positron emission tomography/computed tomography (18F-FDG PET/CT).

Material and methods

In this retrospective cross-sectional study, we enrolled 20 type 2 diabetes patients and 65 controls who had undergone a diagnostic 18F-FDG PET/CT scan and obtained standardized uptake values (SUVs) of pancreas and muscle. Pancreatic SUV was adjusted for background uptake in muscle and for fasting blood glucose concentrations

SUBMITTER: Bakker GJ 

PROVIDER: S-EPMC6424390 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature