Detection of breast cancer lymph node metastases in frozen sections with a point-of-care low-cost microscope scanner.

ABSTRACT:

Background

Detection of lymph node metastases is essential in breast cancer diagnostics and staging, affecting treatment and prognosis. Intraoperative microscopy analysis of sentinel lymph node frozen sections is standard for detection of axillary metastases but requires access to a pathologist for sample analysis. Remote analysis of digitized samples is an alternative solution but is limited by the requirement for high-end slide scanning equipment.

Objective

To determine whether the image quality achievable with a low-cost, miniature digital microscope scanner is sufficient for detection of metastases in breast cancer lymph node frozen sections.

Methods

Lymph node frozen sections from 79 breast cancer patients were digitized using a prototype miniature microscope sca

SUBMITTER: Holmstrom O 

PROVIDER: S-EPMC6424449 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature