A stochastic simulation of skeletal muscle calcium transients in a structurally realistic sarcomere model using MCell.

ABSTRACT: Skeletal muscle contraction is initiated when an action potential triggers the release of Ca2+ into the sarcomere in a process referred to as excitation-contraction coupling. The speed and scale of this process makes direct observation very challenging and invasive. To determine how the concentration of Ca2+ changes within the myofibril during a single activation, several simulation models have been developed. These models follow a common pattern; divide the half sarcomere into a series of compartments, then use ordinary differential equations to solve reactions occurring within and between the compartments. To further develop this type of simulation, we have created a realistic structural model of a skeletal muscle myofibrillar half-sarcomere using MCell software that incorporates the myo

SUBMITTER: Holash RJ 

PROVIDER: S-EPMC6424466 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature