Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion.

ABSTRACT: The deregulation of metabolism is a hallmark of aging. As such, changes in the expression of metabolic genes and the profiles of amino acid levels are features associated with aging animals. We previously reported that the levels of most amino acids decline with age in Caenorhabditis elegans (C. elegans). Glycine, in contrast, substantially accumulates in aging C. elegans. In this study we show that this is coupled to a decrease in gene expression of enzymes important for glycine catabolism. We further show that supplementation of glycine significantly prolongs C. elegans lifespan, and early adulthood is important for its salutary effects. Moreover, supplementation of glycine ameliorates specific transcriptional changes that are associated with aging. Glycine feeds into the methionine cycl

SUBMITTER: Liu YJ 

PROVIDER: S-EPMC6424468 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature