The effectiveness of colchicine combined with mitomycin C to prolong bleb function in trabeculectomy in rabbits.

ABSTRACT:

Purpose

To investigate the potential of colchicine to improve bleb function after trabeculectomy.

Methods

To find the maximum usable colchicine concentration, an ocular irritation study was performed with the Draize test at concentrations of 0.001%, 0.01% and 0.1%. Additionally, the synergistic effect of topical colchicine instillation and MMC application to surgical site was evaluated in a rabbit model by measuring changes after trabeculectomy in intraocular pressure (IOP) and bleb morphology score at 3, 7, 14, 21, 28, 35, 42, and 49 days.

Results

Experiments with a rabbit model of trabeculectomy showed that 0.04% MMC plus 0.01% colchicine was more effective than saline and 0.04% MMC alone in maintaining IOP reduction at days 7-49 (P < 0.01 at all time points) and da

SUBMITTER: Kokubun T 

PROVIDER: S-EPMC6424470 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature