Detection and Prediction of Bioprosthetic Aortic Valve Degeneration.

ABSTRACT:

Background

Bioprosthetic aortic valve degeneration is increasingly common, often unheralded, and can have catastrophic consequences.

Objectives

The authors sought to assess whether ¹⁸F-fluoride positron emission tomography (PET)-computed tomography (CT) can detect bioprosthetic aortic valve degeneration and predict valve dysfunction.

Methods

Explanted degenerate bioprosthetic valves were examined ex vivo. Patients with bioprosthetic aortic valves were recruited into 2 cohorts with and without prosthetic valve dysfunction and underwent in vivo contrast-enhanced CT angiography, ¹⁸F-fluoride PET, and serial echocardiography during 2 years of follow-up.

Results

All ex vivo, degenerate bioprosthetic valves displayed ¹⁸F-fluoride PET

SUBMITTER: Cartlidge TRG 

PROVIDER: S-EPMC6424589 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature