Monocytes Represent One Source of Bacterial Shielding from Antibiotics following Influenza Virus Infection.

ABSTRACT: Methicillin-resistant Staphylococcus aureus has emerged as a significant contributor to morbidity and mortality associated with influenza infection. In this study, we show in a mouse model that preceding influenza infection promotes S. aureus resistance to killing by antibiotics. This resistance coincides with influenza-induced accumulation of inflammatory monocytes in the lung. CCR type 2 (CCR2) is responsible for pulmonary monocyte recruitment after influenza infection. We found that antibiotic-treated Ccr2-deficient (Ccr2^-/-) mice exhibit significantly improved bacterial control and survival from influenza and methicillin-resistant S. aureus coinfection, despite a delay in viral clearance. Mechanistically, our results from in vivo studies indicate that in

SUBMITTER: Fischer KJ 

PROVIDER: S-EPMC6424625 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature