Glutamate-sensitive imaging and evaluation of cognitive impairment in multiple sclerosis.

ABSTRACT:

Background

Cognitive impairment (CI) profoundly impacts quality of life for patients with multiple sclerosis (MS). Dysfunctional regulation of glutamate in gray matter (GM) has been implicated in the pathogenesis of MS by post-mortem pathological studies and in CI by in vivo magnetic resonance spectroscopy, yet GM pathology is subtle and difficult to detect using conventional T₁- and T₂-weighted magnetic resonance imaging (MRI). There is a need for high-resolution, clinically accessible imaging techniques that probe molecular changes in GM.

Objective

To study cortical GM pathology related to CI in MS using glutamate-sensitive chemical exchange saturation transfer (GluCEST) MRI at 7.0 Tesla (7T).

Methods

A total of 20 patients with relapsing-remit

SUBMITTER: O'Grady KP 

PROVIDER: S-EPMC6424643 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature