Backbone ¹H, ¹³C, and ¹⁵N resonance assignments of deubiquitinase A in non-phosphorylated and phosphorylated forms.

ABSTRACT: Ubiquitination is one of the most prevalent forms of post-translational modifications that are important for regulating many cellular processes in eukaryotes. Deubiquitinases are proteases that hydrolyze the isopeptide or peptide bonds formed between ubiquitin and the target proteins or within a polyubiquitin chain. Deubiquitinase A (DUBA) is a deubiquitinase known to be a negative regulator of innate immune responses in humans by suppressing production of type I interferons (INF-I). Excess INF-I production has been associated with autoimmune diseases. Phosphorylation of a single serine residue at position 177 is essential for the protease activity of DUBA. The structural and mechanistic basis of DUBA activation by phosphorylation and substrate specificity is not well understood. Here, we

SUBMITTER: Kabra A 

PROVIDER: S-EPMC6424661 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature