Genetics of Bone and Muscle Interactions in Humans.

ABSTRACT:

Purpose of review

To summarize the evidence from recent studies on the shared genetics between bone and muscle in humans.

Recent findings

Genome-wide association studies (GWAS) have successfully identified a multitude of loci influencing the variability of different bone or muscle parameters, with multiple loci overlapping between the traits. In addition, joint analyses of multiple correlated musculoskeletal traits (i.e., multivariate GWAS) have underscored several genes with possible pleiotropic effects on both bone and muscle including MEF2C and SREBF1. Notably, several of the proposed pleiotropic genes have been validated using human cells or animal models. It is clear that the study of pleiotropy may provide novel insights into disease pathophysiology potentially leading

SUBMITTER: Trajanoska K 

PROVIDER: S-EPMC6424938 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature