Effect of trans(NO, OH)-[RuFT(Cl)(OH)NO](PF₆) ruthenium nitrosyl complex on methicillin-resistant Staphylococcus epidermidis.

ABSTRACT: Antibiotic resistance is becoming a global scourge with 700,000 deaths each year and could cause up to 10 million deaths by 2050. As an example, Staphylococcus epidermidis has emerged as a causative agent of infections often associated with implanted medical devices. S. epidermidis can form biofilms, which contribute to its pathogenicity when present in intravascular devices. These staphylococci, embedded in the biofilm matrix, are resistant to methicillin, which had long been the recommended therapy and which has nowadays been replaced by less toxic and more stable therapeutic agents. Moreover, current reports indicate that 75 to 90% of Staphylococcus epidermidis isolates from nosocomial infections are methicillin-resistant strains. The challenge of successfully combating antibiotics resi

SUBMITTER: Boce M 

PROVIDER: S-EPMC6424994 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature