Neuroregeneration in Parkinson's Disease: From Proteins to Small Molecules.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, the lifetime risk of developing this disease is 1.5%. Motor diagnostic symptoms of PD are caused by degeneration of nigrostriatal dopamine neurons. There is no cure for PD and current therapy is limited to supportive care that partially alleviates disease signs and symptoms. As diagnostic symptoms of PD result from progressive degeneration of dopamine neurons, drugs restoring these neurons may significantly improve treatment of PD.

Method

A literature search was performed using the PubMed, Web of Science and Scopus databases to discuss the progress achieved in the development of neuroregenerative agents for PD. Papers published before early 2018 were taken into account.

Res

SUBMITTER: Sidorova YA 

PROVIDER: S-EPMC6425072 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature