Steroid-Free Immune Suppression Impairs Glycemic Control in a Healthy Cynomolgus Monkey.

ABSTRACT: The need for chronic immune suppression (IS) is one of the hurdles precluding widespread use of islet cell transplantation to restore glycemic control in patients with type 1 diabetes. We report the case of a healthy nonhuman primate (NHP) treated on and off for over 2.5 years with steroid-free IS, consisting of daclizumab induction and maintenance therapy with rapamycin and low dose tacrolimus. Treatment for 1 year resulted in a striking destabilization of glycemic control, with concomitant decreases in fasting c-peptide and insulin levels. Although these changes gradually reversed during a wash out period of 7 months, retreatment with the same therapy led to accelerated deterioration in glycemic control. Intravenous glucose tolerance and percentage of glycosylated hemoglobin testing furt

SUBMITTER: Berman DM 

PROVIDER: S-EPMC6425109 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature