Exploration of attractor modules for sporadic amyotrophic lateral sclerosis via systemic module inference and attract method.

ABSTRACT: Sporadic amyotrophic lateral sclerosis (SALS) is a devastating neurodegenerative disorder. However, the understanding of SALS is still poor. This research aimed to excavate attractor modules for SALS by integrating the systemic module inference and attract method. To achieve this, gene expression data and protein-protein data were recruited and preprocessed. Then, based on the Spearman's correlation coefficient (SCC) of the interactions under these two conditions, two PPI networks separately with 870 nodes (979 interactions) in normal control group and 601 nodes (777 interactions) in SALS group were built. Systemic module inference method was performed to identify the modules, and attract method was used to identify attractor modules. Finally, pathway enrichment analysis was performed to d

SUBMITTER: Zhang F 

PROVIDER: S-EPMC6425136 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature