Performance of Antigen Concentration Thresholds for Attributing Fever to Malaria among Outpatients in Angola.

ABSTRACT: The density of malaria parasites is a key determinant of whether an infected individual develops fever. While the pyrogenic threshold for malaria parasite density has been well studied, there are no analogous data on the antigen levels associated with fever during infection. Samples from 797 afebrile and 457 febrile outpatients from two provinces in Angola with known concentrations of histidine-rich protein 2 (HRP2), aldolase, and lactate dehydrogenase (LDH) antigens were analyzed by Bayesian latent class modeling to attribute malarial etiology to the fevers and to estimate the sensitivity and specificity of different antigen thresholds for detection of malaria fevers. Among patients with aldolase or LDH levels detectable with a bead-based assay, the concentrations of these two antigens di

SUBMITTER: Plucinski MM 

PROVIDER: S-EPMC6425161 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature