Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis.

ABSTRACT:

Introduction

The aim of this meta-analysis was to summarize the evidence on the serum/plasma leptin concentrations in breast cancer (BC) patients, as well as the associations between leptin G-2548A gene polymorphisms and susceptibility to BC.

Material and methods

Potentially relevant studies about serum/plasma leptin levels and leptin G-2548A gene polymorphism were selected using the electronic databases PubMed, EMBASE and The Cochrane Library (from January 1 1995 to Jun 30 2017, no language restrictions). The potential sources of heterogeneity were assessed by the Q statistic and quantified using I² ; publication bias was qualitatively assessed by funnel plot and quantitatively assessed by Egger's linear regression test.

Results

SUBMITTER: Hao JQ 

PROVIDER: S-EPMC6425221 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature